MM-111 is designed to inhibit ErbB3 (HER3) receptor signaling in ErbB2 positive (HER2 or ErbB2+) cancer. Overexpression of the ErbB2 cell surface receptor has been reported in 7-34 percent of gastric cancers, and research has shown that ErbB3 levels are associated with poor prognosis in gastric cancer, which may contribute to resistance to therapy over time.
"MM-111's bispecific design allows it to attach to ErbB2 receptors on the surface of tumor cells and then inhibit its target ErbB3. Signaling through ErbB3 appears crucial to a tumor's growth and survival during chemotherapy," said
Merrimack is initiating a Phase 2 trial testing MM-111 in combination with paclitaxel or paclitaxel and trastuzumab in patients with advanced gastric, esophageal and gastroesophageal junction cancers. For more information on this study, please visit www.clinicaltrials.gov.
Therapy and Poster Overview
-- MM-111 is a bispecific antibody designed to target ErbB3 in cancer cells that are characterized by overexpression of the ErbB2 (HER2) cell receptor. MM-111 is engineered to uniquely address the tumor growth and survival signaling promoted by the ErbB2, ErbB3 and heregulin signaling complex.
-- General Poster Session A: Cancers of the Esophagus and Stomach,
Thursday, January 24, 2013, 12:00PM— 2:00PM, Moscone West Building
Any statements in this press release about future expectations, plans and prospects for Merrimack constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, as amended. Actual results may differ materially from those indicated by such forward-looking statements. Merrimack anticipates that subsequent events and developments will cause its views to change. However, while Merrimack may elect to update these forward-looking statements at some point in the future, Merrimack specifically disclaims any obligation to do so.
Kathleen Petrozzelli GallagherMerrimack 617-441-1043 firstname.lastname@example.org Liz BryanSpectrum 202-955-6222 email@example.com
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