Merrimack Strengthens SHERLOC Study of MM-121 in Non-small Cell Lung Cancer
The global, randomized, open-label SHERLOC study is assessing progression-free survival in patients who have received MM-121 in combination with docetaxel, compared with docetaxel alone. In response to rapid enrollment and robust clinical interest, Merrimack will expand the accrual target from 80 to 100 patients. Patients must have received a prior platinum-based therapy, as well as prior immunotherapy where available and clinically indicated.
"We are encouraged by the tremendous interest in the SHERLOC study over the past year, which has been enrolling far faster than we had projected, reflecting what we believe is the significant unmet medical need among this patient population," said
With the expanded patient pool and accelerated enrollment, Merrimack continues to anticipate top-line data from the SHERLOC study in the second half of 2018.
MM-121, also known as seribantumab, is Merrimack's wholly owned, fully human anti-HER3 (ErbB3) monoclonal antibody that targets phenotypically distinct heregulin-positive cancer cells within solid tumors. Heregulin-positive cancer cells are characterized by their ability to escape the effects of targeted, cytotoxic and anti-endocrine therapies. Identification of heregulin-positive cancer cells by RNA-ISH may identify tumors at risk for rapid clinical progression. Seribantumab, when used in the combination setting, is designed to block the heregulin/HER3 signaling axis to make these cells more responsive to the effects of the combination therapy and deliver improved clinical outcomes.
Merrimack is a biopharmaceutical company based in Cambridge, Massachusetts that is outthinking cancer to ensure that patients and their families live fulfilling lives. Its mission is to transform cancer care through the smart design and development of targeted solutions based on a deep understanding of cancer pathways and biological markers. All of Merrimack's development programs, including four clinical studies and six candidates in preclinical development, fit into its strategy of 1) understanding the biological problems it is trying to solve, 2) designing specific solutions and 3) developing those solutions for biomarker-selected patients. This three-pronged strategy seeks to ensure optimal patient outcomes. For more information, please visit Merrimack's website at www.merrimack.com.
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